Molecular Analysis of Thyroid Tumors
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Feriyl Bhaijee & Yuri E. Nikiforov
- چاپ و سال / کشور: 2011
Description
Thyroid cancer is the most common endocrine malignancy, and its incidence is rising in the USA and other countries. Papillary and follicular thyroid carcinomas are the two most common types of thyroid cancer. Nonoverlapping genetic alterations, including BRAF and RAS point mutations, and RET/PTC and PAX8/PPARم rearrangements, are found in more than 70% of papillary and follicular thyroid carcinomas. These represent the most common genetic alterations in thyroid cancer, as well as molecular markers of diagnostic and prognostic significance. The use of these and other emerging molecular markers will likely improve the diagnosis of malignancy in thyroid nodules as well as facilitate more individualized operative and postoperative management. Herein, we provide a brief overview of the common genetic alterations in papillary and follicular thyroid carcinoma and discuss the diagnostic and prognostic significance thereof.
Endocr Pathol DOI 10.1007/s12022-011-9170-y Science+Business Media, LLC 2011
