MicroRNAs in the Human Pituitary
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Milani Sivapragasam & Fabio Rotondo & Ricardo V. Lloyd & Bernd W. Scheithauer & Michael Cusimano & Luis V. Syro & Kalman Kovacs
- چاپ و سال / کشور: 2011
Description
MicroRNAs (miRNAs) represent a novel class of small RNA molecules that play a crucial role as posttranscriptional regulators of gene expression. As evidence for the involvement of miRNAs in various cellular processes increases, it is important to examine how miRNAs regulate gene expression. In the pituitary, aberrant miRNA expression is strongly linked with neoplasia, thus suggesting they play a role in the control of cell proliferation in adenomas. Research has built fundamental connections between aberrant miRNA expression and clinicopathological features of pituitary adenomas. Moreover, deregulated expression of miRNA target genes is often implicated in important biological pathways and thus provides significant insight into the role of miRNAs in tumorigenesis. This review will assess the significance of miRNAs in pituitary patholog
Endocr Pathol DOI 10.1007/s12022-011-9167-6 Science+Business Media, LLC 2011
