Gender differences in clinicopathologic features and outcomes of esophageal cancer patients treated surgically
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Naohiko Koide Masato Kitazawa Daisuke Komatsu Akira Suzuki Shinichi Miyagaw
- چاپ و سال / کشور: 2010
Description
Background We investigated the clinicopathologic features and long-term outcomes after surgery of Japanese women with esophageal cancer in comparison to those of men. Methods A total of 136 patients with esophageal cancer were surgically treated between 1996 and 2008 (22 [16.2%] women and 114 men). Gender differences in these patients were retrospectively investigated. Results Women undergoing esophagectomy for esophageal cancer showed lower frequencies of cigarette smoking (p\0.0001) and alcohol consumption (p\0.0001) compared to men. Preoperative co-morbidities in women were fewer than those in men (p\0.001). Regarding the clinicopathologic features of esophageal cancer, women frequently had superficial cancer and no node metastasis (p\0.05). Women had lower-level morbidity after surgery (p\0.05), but no mortality after surgery was observed in men or women. Although there was no difference in other causes of death after surgery between them, recurrence/metastasis after surgery was more frequent in men than women (p\0.05). The 5-year survival rate after surgery was higher in women than men (p\0.05), but gender difference was not an independent prognostic factor. Conclusions Significant gender differences in patients with esophagectomy were observed regarding the preoperative condition, clinicopathologic features, postoperative condition, and long-term outcome after surgery. It was suggested that the more favorable outcome of women with esophageal cancer was associated with their earlier stages of esophageal cancer.
Esophagus (2011) 8:107–112 DOI 10.1007/s10388-011-0271-y Received: 16 May 2010 / Accepted: 28 February 2011 / Published online: 17 March 2011
