Acoustic overstimulation-induced apoptosis in Wbrocytes of the cochlear spiral limbus of mice
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Yong Cui · Guang-wei Sun · Daisuke Yamashita · Sho Kanzaki · Tatsuo Matsunaga · Masato Fujii · Kimitaka Kaga · Kaoru Ogawa
- چاپ و سال / کشور: 2011
Description
Fibrocytes of the spiral limbus are thought to play a signiWcant role in maintaining ion homeostasis in the cochlea. The present study measured physiological and morphological changes in spiral limbus of mice in response to noise exposure. 6-week-old male C3H/HeJJcl mice were exposed to octave-band noise (120 dB SPL) for 2 h and evaluated at a series of times thereafter, up to 8 weeks. Permanent hearing loss resulted in the mice, as assessed by auditory brainstem response (ABR) recordings. The Wbrocytes loss was found in the spiral limbus of the apical turn, which has been proved to be induced by apoptosis. These results suggest that noise exposure might result in apoptosis of Wbrocytes in spiral limbus, which suggest a mechanism for noise-induced hearing loss.
Eur Arch Otorhinolaryngol (2011) 268:973–978, Received: 10 July 2010 / Accepted: 6 January 2011 / Published online: 19 January 2011 © Springer-Verlag 2011
