EVectiveness of cidofovir intralesional treatment in recurrent respiratory papillomatosis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Maigorzata Wierzbicka · Joanna Jackowska · Anna Bartochowska · Agata JَzeWak · Witold Szyfter · Witold Kddzia
- چاپ و سال / کشور: 2011
Description
To present the results of recurrent respiratory papillomatosis (RRP) treatment with surgical excision and adjuvant anti-viral cidofovir intralesional use and to examine the correlation between the cidofovir eVectiveness and the patient previous history of multiple larynx procedures, age, extension of lesion and dose. 32 patients with laryngeal papillomas were treated with cidofovir in our Department between I.2009 and I.2011. The number of previous RRP debulking procedures ranged from 1 to 100. The intensity of papillomatosis diVered from one anatomic site and moderate growth to four or Wve localizations with heavy extension. The number of injections per patient varied from 1 to 7, and the total volume of 5 mg/ml solution varied from 2 to 33 ml. The injections were combined with laser debulking of the lesions. In disperse papillomata, the injections were administered in particular anatomical sites in 4–6 weeks intervals, in massive lesions injections were repeated in the same anatomical site in 2–4 weeks. Complete remission was observed in 18 out of 32 patients. 13 patients showed remission in a place of cidofovir injection. One patient did not react to the drug. In four patients, new changes in injection places appeared. In two patients, hepatic toxic side eVects were observed. Intralesional cidofovir injection has been shown to be an eVective and safe therapy for laryngeal papillomatosis and should be considered in those patients who experienced disease relapse.
Eur Arch Otorhinolaryngol (2011) 268:1305–1311, Received: 8 February 2011 / Accepted: 29 March 2011 / Published online: 26 April 2011 © The Author(s) 2011. This article is published with open access at Springerlink.com
