Vitamin D status is associated with disease-free survival and overall survival time in patients with squamous cell carcinoma of the upper aerodigestive tract
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Markus Gugatschka Karl Kiesler Barbara Obermayer-Pietsch Andrea Groselj-Strele Antonia Griesbacher Gerhard Friedrich
- چاپ و سال / کشور: 2011
Description
Considerable clinical and experimental data suggest that vitamin D plays a role in pathogenesis and progression of cancer; nevertheless clinical data for head and neck squamous cell carcinoma (HNSCC) are not available. The aim of our study was to associate tumor and clinical characteristics with status of vitamin D [25-hydroxyvitamin D (25(OH)D)]. 88 patients with newly diagnosed squamous cell carcinoma of the head and neck were included in the study. A blood draw was taken at the time of diagnosis. The observation period lasted from 2006 until 2010. Results: When compared to a cohort from an epidemiological study, serum levels of 25(OH)D were significantly reduced in patients with HNSCC. We furthermore found disease-free survival, as well as overall survival times to be significantly associated with 25(OH)D levels. In conclusion, results from our study suggest an influence of vitamin D status on cancer incidence, as well as on mortality of HNSCC.
Eur Arch Otorhinolaryngol (2011) 268:1201–1204, Received: 5 October 2010 / Accepted: 23 December 2010 / Published online: 8 January 2011 Springer-Verlag 2011
