Treatment of lymphatic malformations of head and neck with OK-432 sclerotherapy induce systemic inXammatory response
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Mervi Nنrkiِ-Mنkelن · Teppo Mنkelن · Pia Saarinen · Pنivi Salminen · Ilkka Julkunen · Anne Pitkنranta
- چاپ و سال / کشور: 2011
Description
Systemic immune responses after OK-432 (Picibanil) sclerotherapy in patients with head and neck lymphatic malformations (LM) were examined to achieve a better understanding of the mechanism of OK-432 sclerotherapy and to evaluate the long-term treatment outcome. Serum samples from 17 consecutive patients with head and neck LMs were collected during a total of 26 OK-432 treatment episodes. Serum C-reactive protein (CRP), interleukins (IL) 1, 6, 8, 10, tumor necrosis factor (TNF)-, interferon (IFN)-, RANTES, immune protein (IP)-10 and macrophage chemoattractant protein (MCP)-1 as well as blood leukocyte counts were determined. Clinical outcome of the treatment was evaluated at the last visit and from patient Wles. Elevated serum levels of IP-10 (means at baseline 702 ng/L, after 1 day 1180 ng/L, after 4 weeks 691 ng/L) were seen on day one after OK-432 sclerotherapy (p < 0.05). C-reactive protein and leukocyte counts 1 day after treatment diVered statistically signiWcantly (p < 0.05) from the baseline. No signiWcant diVerences with other cytokines investigated were observed. Patients with macrocystic LM responded better than patients with microcystic LM (p = 0.01). The elevated levels of IP-10, C-reactive protein and leukocyte levels indicate that OK-432 sclerotherapy induces systemic immune responses in patients with LM. The mechanisms of OK-432 sclerotherapy are still not precisely understood, but the IP-10 elevation may reXect local antiangiogenetic properties of immunoactivation induced by OK-432.
Eur Arch Otorhinolaryngol (2011) 268:123–129, Received: 18 April 2010 / Accepted: 28 June 2010 / Published online: 16 July 2010 © Springer-Verlag 2010
