Association of PPAR polymorphisms with cytokine levels in allergic rhinitis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Magdolna Krasznai Kinga Szaniszlo Helga Kraxner Eszter Vargha Margit Kovacs Edit Kaszas Gyorgyi Mezei Endre Cserhati Zoltan Borocz
- چاپ و سال / کشور: 2011
Description
Our aim was to study the association of Pro12Ala and exon6 C161T polymorphisms of PPARgamma and intron7 G/C polymorphisms of PPAR-alpha with clinical symptoms, peak nasal inspiratory flow values, serum soluble TNF-alpha, TNF-R1, Fas, Fas ligand and IgE concentrations in patients with seasonal allergic rhinitis during and after pollen season. We performed a follow- up study of 66 Hungarian patients with seasonal allergic rhinitis and 180 healthy referent subjects. We used PCR-RFLP technique and ELISA. The distribution of mutant alleles of PPAR-gamma and -alpha did not differ in patients and referent subjects. Patients carrying the mutant 12Ala, exon6 161T alleles of PPAR-gamma and intron7 C allele of PPAR-alpha had significantly higher clinical symptom score values, TNF-alpha and IgE levels and lower peak nasal inspiratory flow values during and after pollen season. The results indicated that nuclear receptors PPAR-gamma and PPAR-alpha are involved in the regulation of inflammatory mediator production in patients with seasonal allergic rhinitis and polymorphisms of the receptors are very likely to contribute to the heterogeneity of clinical and immunological parameters of allergic patients.
Eur Arch Otorhinolaryngol DOI 10.1007/s00405-011-1710-z, Received: 22 February 2011 / Accepted: 5 July 2011
