ADC changes in schizophrenia: a diffusion-weighted imaging study
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Igor Nenadic Gerd Wagner Daniel Gu¨ llmar Claudia Schachtzabel Katrin von Consbruch Sabine Ko¨hler Kathrin Koch Martin Roebel C. Chr
- چاپ و سال / کشور: 2011
Description
Studies using diffusion tensor imaging (DTI) have shownmultifocal reduction in anisotropy ofwhitematter fibre tracts in schizophrenia, and a few of these also suggest changes in apparent diffusion coefficient (ADC). In this study, we assessed ADC in 18 patients with schizophrenia and 18 healthy controls using a voxel-based approach. We did not find evidence of statistically significant changes in ADC in either direction at P\0.05 (FDR corrected) using different smoothing filter sizes; only at an uncorrected threshold of P\0.001 did we find an increase in a small right prefrontal area close to our previous FA finding. Our findings therefore do not supportADC changes to be amarker ofwhite matter or grey matter abnormalities in schizophrenia. Changes in other parameters like fractional anisotropy (FA) might be a more sensitive indicator of white matter pathology in this disorder
Eur Arch Psychiatry Clin Neurosci (2011) 261:213–216 DOI 10.1007/s00406-010-0150-x, Received: 24 May 2010 / Accepted: 1 September 2010 / Published online: 26 September 2010
