Proteome analyses of cultured astrocytes treated with MK-801 and clozapine: similarities with schizophrenia
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Daniel Martins-de-Souza Maria Lebar Christoph W. Turck
- چاپ و سال / کشور: 2011
Description
On the basis of impaired glutamatergic transmission and the potential role of astrocytes in schizophrenia, we treated cultured astrocytes with MK-801, an NMDA-receptor antagonist, to investigate whether the resulting proteome changes are similar to those we found in our earlier proteome analysis of schizophrenia human brain tissue as well as to better comprehend the role of astrocytes in the disorder. Indeed, there are similarities. Furthermore, to verify the efficacy of clozapine and its effect over the proteome, we treated MK-801-treated astrocytes with clozapine. Interestingly, clozapine reversed protein changes induced by MK-801. The treatment of cell cultures with neural transmission agonists and antagonists might provide useful insights about psychiatric disorders
Eur Arch Psychiatry Clin Neurosci (2011) 261:217–228 DOI 10.1007/s00406-010-0166-2, Received: 28 May 2010 / Accepted: 28 October 2010 / Published online: 19 November 2010
