Differential expression of HINT1 in schizophrenia brain tissue
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Jeeva Varadarajulu • Andrea Schmitt • Peter Falkai • Murtada Alsaif • Christoph W. Turck • Daniel Martins-de-Souza
- چاپ و سال / کشور: 2011
Description
Recent findings in the literature suggest a relation between histidine triad nucleotide-binding protein- 1 (HINT1) and psychiatric disorders such as major depression, anxiety, and schizophrenia, although its physiological roles are not completely comprehended. Using Western blot, we compared HINT1 protein expression in the postmortem dorsolateral prefrontal cortex and thalamus of schizophrenia patients and healthy controls for contributing to elucidate the role of HINT1 in schizophrenia pathophysiology. HINT1 was found to be downregulated in the dorsolateral prefrontal cortex and upregulated in the thalamus. Our results combined to previous studies in human samples and preclinical models support the notion that HINT1 must be more explored as a potential target for psychiatric disorders.
Eur Arch Psychiatry Clin Neurosci DOI 10.1007/s00406-011-0216-4, Received: 2 April 2011 / Accepted: 25 April 2011
