Chlamydia trachomatis infection during pregnancy associated with preterm delivery: a population-based prospective cohort study
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : G. Ingrid J. G. Rours Liesbeth Duijts Henriette A. Moll Lidia R. Arends Ronald de Groot Vincent W. Jaddoe Albert Hofman Eric A. P. Steege
- چاپ و سال / کشور: 2011
Description
Chlamydia trachomatis infection is the most prevalent bacterial sexually transmitted infection and may influence pregnancy outcome. This study was conducted to assess the effect of chlamydial infection during pregnancy on premature delivery and birthweight. Pregnant women attending a participating midwifery practice or antenatal clinic between February 2003 and January 2005 were eligible for the study. From 4,055 women self-administered questionnaires and urine samples, tested by PCR, were analysed for C. trachomatis infection. Pregnancy outcomes were obtained from midwives and hospital registries. Gestational ages and birthweights were analysed for 3,913 newborns. The C. trachomatis prevalence was 3.9%, but varied by age and socio-economic background. Chlamydial infection was, after adjustment for potential confounders, associated with preterm delivery before 32 weeks (OR 4.35 [95% CI 1.3, 15.2]) and 35 weeks gestation (OR 2.66 [95% CI 1.1, 6.5]), but not with low birthweight. Of all deliveries before 32 weeks and 35 weeks gestation 14.9% [95% CI 4.5, 39.5] and 7.4% [95% CI 2.5, 20.1] was attributable to C. trachomatis infection. Chlamydia trachomatis infection contributes significantly to early premature delivery and should be considered a public health problem, especially in young women and others at increased risk of C. trachomatis infection.
Eur J Epidemiol (2011) 26:493–502 DOI 10.1007/s10654-011-9586-1 Received: 25 November 2010 / Accepted: 15 April 2011 / Published online: 3 May 2011
