Orthopaedic antimicrobial prophylaxis in the United Kingdom
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : R. S. Aujla E. Peysakhova A. Gulihar G. J. S. Taylor
- چاپ و سال / کشور: 2010
Description
Using the Freedom of Information Act, a fivepoint questionnaire was sent to all NHS Trusts in the United Kingdom: Eighty two per cent of NHS Trusts in the UK who had an orthopaedic department replied. The top three antimicrobial prophylaxis regimes in orthopaedic surgery were cefuroxime alone (trauma 48%, elective 56%), flucloxacillin plus gentamicin (trauma 16%, elective 19%) and co-amoxiclav alone (trauma 10%, elective 5.6%). Forty nine per cent of Trusts involved changed antimicrobial prophylaxis regimes between August 2005 and July 2008, to restrict the use of cefuroxime. There was a 74% difference in C. difficile rates in Trusts who use cefuroxime when compared to any other antimicrobial regime. In Trusts that changed away from cefuroxime, there was a 33% reduction in C. difficile rates. Clostridium difficile rates were six times higher in trauma than elective surgery across the UK. Few Trusts (trauma 7.7%, elective 7.6%) used antimicrobial prophylaxis regimes that have a low-risk association with C. difficile infection.
Eur J Orthop Surg Traumatol (2011) 21:21–25 DOI 10.1007/s00590-010-0660-2 Received: 27 April 2010 / Accepted: 13 May 2010 / Published online: 26 June 2010
