Educational paper Syndromic forms of primary immunodeficiency
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Rogier Kersseboom & Alice Brooks & Corry Weemaes
- چاپ و سال / کشور: 2011
Description
The syndromic primary immunodeficiencies are disorders in which not only the immune system but also other organ systems are affected. Other features most commonly involve the ectodermal, skeletal, nervous, and gastrointestinal systems. Key in identifying syndromic immunodeficiencies is the awareness that increased susceptibility to infections or immune dysregulation in a patient known to have other symptoms or special features may hint at an underlying genetic syndrome. Because the extraimmune clinical features can be highly variable, it is more difficult establishing the correct diagnosis. Nevertheless, correct diagnosis at an early age is important because of the possible treatment options. Therefore, diagnostic workup is best performed in a center with extensive expertise in this field, having immunologists and clinical geneticists, as well as adequate support from a specialized laboratory at hand. This paper provides the general pediatrician with the main clinical features that are crucial for the recognition of these syndrome
Eur J Pediatr (2011) 170:295–308 Received: 19 November 2010 / Accepted: 11 January 2011 / Published online: 22 February 2011
