Congenital acute lymphoblastic leukemia: a two-case report and a review of the literature
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Ma Pilar Bas Suلrez & Jezabel Lَpez Brito & Candelaria Santana Reyes & Manuel Gresa Muٌoz & Rosario Diaz Pulido & Jose Carlos Lodos Rojas
- چاپ و سال / کشور: 2011
Description
Congenital leukemia is a rare disease with particular biological and clinical characteristics which differs from those of older children and adults. Here, we describe two cases of congenital acute lymphoblastic leukemia in two newborns with different clinical presentations (leukemia cutis vs. splenomegaly and respiratory distress) and fatal outcome. Both cases shared the expression of myeloid antigens (CD65) and cytogenetic disorders involving the MLL gene (location 11q23) which are associated to extremely poor prognosis.
Eur J Pediatr (2011) 170:531–534 DOI 10.1007/s00431-010-1339-8 Received: 14 July 2010 / Accepted: 20 October 2010 / Published online: 3 November 2010
