Glucocorticoids in the treatment of neonatal meconium aspiration syndrome
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Daniela Mokra & Juraj Mokry
- چاپ و سال / کشور: 2011
Description
Meconium aspiration syndrome is a serious neonatal disease with complex pathophysiology. With respect to the contribution of meconium-induced lung edema, inflammation and vasoconstriction on the course of the disease, glucocorticoids are increasingly used in the treatment of MAS despite the fact that principal questions on the choice of GCs derivative, mode of delivery and dosing have not been answered yet. To bring a complex insight into the topic, this article reviews the pathomechanisms of MAS, mechanisms of action of GCs, as well as the advantages and disadvantages of GCs administration in experimental models and newborns with MAS.
Eur J Pediatr DOI 10.1007/s00431-011-1453-2 Received: 13 October 2010 / Accepted: 14 March 2011
