Detection of non-palpable breast cancer in asymptomatic women by using unenhanced diffusion-weighted and T2-weighted MR imaging: comparison with mammography and dynamic contrast-enhanced MR imaging
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Hidetake Yabuuchi, Yoshio Matsuo, Shunya Sunami, Takeshi Kamitani, Satoshi Kawanami Taro Setoguchi, Shuji Sakai, Masamitsu Hatakenaka, Makoto Kubo, E
- چاپ و سال / کشور: 2010
Description
Objective To compare the detectability of non-palpable breast cancer in asymptomatic women by using mammography (MMG), dynamic contrast-enhanced MR imaging (DCE-MRI) and unenhanced MR imaging with combined diffusion-weighted and T2-weighted images (DWI+T2WI). Methods Forty-two lesions in 42 patients with non-palpable breast cancer in asymptomatic women were enrolled. For the reading test, we prepared a control including 13 normal and 8 benign cases. Each imaging set included biplane MMG, DCE-MRI and DWI+T2WI. Five readers were asked to rate the images on a scale of 0 to 100 for the likelihood of the presence of cancer and the BI-RADS category. Confidence level results were used to construct receiver operating characteristic analysis. Sensitivity and specificity were calculated for each technique. Results DWI+T2WI showed higher observer performances (area under the curve, AUC, 0.73) and sensitivity (50%) for the detection of non-palpable breast cancer than MMG alone (AUC 0.64; sensitivity 40%) but lower than those of DCE-MRI (AUC 0.93; sensitivity 86%). A combination of MMG and DWI+T2WI exhibited higher sensitivity (69%) compared with that of MMG alone (40%). Conclusion DWI+T2WI could be useful in screening breast cancer for patients who cannot receive contrast medium and could be used as a new screening technique for breast cancer.
Eur Radiol (2011) 21: 11–17 DOI 10.1007/s00330-010-1890-8 Received: 13 March 2010 Revised: 10 June 2010 Accepted: 21 June 2010 Published online: 18 July 2010
