Interval growth of probably benign breast lesions on follow-up ultrasound: how can these be managed?
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Hee Jung Moon & Eun-Kyung Kim & Jin Young Kwak & Jung Hyun Yoon & Min Jung Ki
- چاپ و سال / کشور: 2010
Description
Objectives To investigate the malignancy rate in probably benign lesions with interval growth on follow-up ultrasound (US) and the cut-off values for predicting malignancy. Methods By retrospective reviewing 19,435 US examinations assessed as probably benign lesions, a total of 214 lesions with interval growth in 199 patients were included. The increased volume (%V),%V per month, the most increased diameter (D), and D per month were compared between malignant and benign lesions. Malignancy rates were compared between lesions with or without newly developed suspicious malignant features. Results Twenty-two (10.3%)malignancies showed significant increase in%V,%V per month, D, and D per month compared with 192 (89.7%) benign lesions (p=0.0083, <0.0001, <0.0001, and <0.0001, respectively). Fifteen (38.5%) of 39 lesions where suspicious features developed proved malignant, whereas 7 (4%) out of 175 without were malignant (p= 0.0011). In nodules without suspicious features, 24.2% of%V per month and 1.9 mm of D per month showed high sensitivity (85.7% and 71.4%) and specificity (67.8% and 97.6%) for predicting malignancy. Conclusions Probably benign lesions with interval growth should undergo prompt biopsy because of the 10.3% malignancy rate. In lesions where suspicious features developed, the malignancy rate increased to 38.5%.
Eur Radiol (2011) 21:908–918 DOI 10.1007/s00330-010-2012-3 Received: 16 July 2010 / Revised: 1 October 2010 / Accepted: 30 October 2010 / Published online: 27 November 2010
