Pulmonary langerhans cell histiocytosis in adults: high-resolution CT—pathology comparisons and evolutional changes at CT
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Hyo Jin Kim & Kyung Soo Lee & Takeshi Johkoh & Noriyuki Tomiyama & Ho Yun Lee & Joungho Han & Tae Sung Kim
- چاپ و سال / کشور: 2011
Description
Objective To compare high-resolution (HR) CT and histopathological findings and to evaluate serial CT findings in pulmonary Langerhans cell histiocytosis (PLCH). Methods We reviewed CTof lung lesions in 27 adults (M:F= 20:7, mean age, 41±12.3 years) with PLCH. After evaluating lung abnormalities including nodules, micronodules, thickwalled, thin-walled, and bizarre-shaped cysts and reticulation, observers compared CT findings obtained at lung biopsy sites with histopathological findings. The final CT was compared with the initial CT to determine disease extent changes. Results The most frequently observed patterns of lung abnormalities were micronodules (n=24, 89%), thickwalled (n=22, 82%), and thin-walled (n=22, 82%) cysts. Even thin-walled and bizarre cysts harboured active inflammatory Langerhans cell sheets and eosinophils in their walls. In thin-walled cysts, we noted pericystic inflammatory cell infiltrations along the alveolar walls, as well as pericystic emphysema. Thin-walled or bizarre cysts demonstrated a tendency to coalesce with surrounding cysts via their cystic wall destruction. Fourteen (52%) patients showed improvement and nine (33%) showed progressing disease. Conclusion More than half of patients with pulmonary PLCH show improvement at follow-up CT. Even thinwalled cysts harbour active inflammatory cells on histopathology and exhibit improvement at follow-up CT.
Eur Radiol (2011) 21:1406–1415 DOI 10.1007/s00330-011-2075-9 Received: 8 November 2010 / Revised: 27 December 2010 / Accepted: 6 January 2011 / Published online: 11 February 2011
