Ultrasound features of malignancy in the preoperative diagnosis of parathyroid cancer: a retrospective analysis of parathyroid tumours larger than 15 mm
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Paul S. Sidhu & Nadia Talat & Preena Patel & Nicola J. Mulholland & Klaus-Martin Schulte
- چاپ و سال / کشور: 2011
Description
Objective Nearly all reported parathyroid cancers are >15 mm at presentation. The objective was to identify ultrasound criteria of malignancy in parathyroid lesions of >15 mm in size. Materials and methods This study was approved by a local ethics committee. A retrospective review of patients identified from a database from 2004–2009 was performed. All patients underwent ultrasound imaging according to the protocol. Two trained observers categorized findings using the predetermined features: shape, calcification, pattern of vascularity, local infiltration and internal lesion gray scale appearances. Results Sixty-nine patients (mean age 54.3 years, range 19– 79 years; male = 16, female = 53) fulfilled the criteria of a parathyroid lesion >15 mm; 8/69 (11.6%) with parathyroid cancer and 61/69 (88.4%) with benign solitary parathyroid adenoma. A high positive predictive value (PPV) for cancer was identified for infiltration (PPV 100%) and calcification (PPV 100%), whilst a high negative predictive value (NPV) was found for the absence of suspicious vascularity (NPV 97.6%), a thick capsule (NPV 96.7) and inhomogeneity (NPV 100%). Conclusion In lesions >15 mm systematic ultrasound assessment of specific features provides a valuable tool to identify parathyroid cancers before surgery.
Eur Radiol (2011) 21:1865–1873 DOI 10.1007/s00330-011-2141-3 Received: 7 January 2011 / Revised: 28 February 2011 / Accepted: 19 March 2011 / Published online: 10 May 2011
