Accuracy of coronary artery stenosis detection with CT versus conventional coronary angiography compared with composite findings from both tests as an enhanced reference standard
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : J. Matthias Kerl & U. Joseph Schoepf & Peter L. Zwerner & Ralf W. Bauer & Joseph A. Abro & Christian Thilo & Thomas J. Vogl & Christopher Her
- چاپ و سال / کشور: 2011
Description
Objective To prospectively compare the accuracy of coronary CT angiography (CCTA) and conventional coronary angiography (CCA) for stenosis detection using composite findings from both tests as an enhanced reference standard. Methods One hundred thirteen patients underwent CCTA and CCA. Per-segment and per-patient accuracy of CCTA compared with initial CCA interpretation were determined. Angiographers were then unblinded to the CCTA results and re-evaluation of the CCA studies was performed with knowledge of CCTA findings, which was used as an enhanced reference standard to compare the diagnostic accuracy of CCTA versus CCA. Results When using the enhanced reference standard instead of initial CCA interpretation, CCTA accuracy for identifying segments (patients) with .50%stenosis increased from 97.7% (96.5%) to 98.1% (98.2%), sensitivity from 90.5% (100%) to 90.8% (100%), and specificity from 98.4% (94.3%) to 98.9% (97.1%). CCTA identified six segments and two patients with stenoses .50% missed on initial CCA interpretation. Compared with the enhanced reference standard the accuracies of CCTA and of initial CCA interpretation were not different (p=0.87). Conclusion CCTA compares favourably with CCA for stenosis detection. Use of a composite reference standard combining findings from both tests can control for the effect of false-negative CCA results when evaluating the accuracy of CCTA.
Eur Radiol (2011) 21:1895–1903 DOI 10.1007/s00330-011-2134-2 Received: 20 December 2010 / Revised: 12 March 2011 / Accepted: 23 March 2011 / Published online: 1 May 2011
