64-row MDCT perfusion of head and neck squamous cell carcinoma: technical feasibility and quantitative analysis of perfusion parameters
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Lorenzo Faggioni, Emanuele Neri, Francesca Cerri, Eugenia Picano, Veronica Seccia, Luca Muscatello, Stefano Sellari Franceschini, Carlo Bartolozzi
- چاپ و سال / کشور: 2010
Description
Objectives To evaluate the technical feasibility of 64-row computed tomography (CT) quantitative perfusion imaging of head and neck squamous cell carcinoma (SCC). Methods Twenty-nine patients with a total of 29 pathologically proven SCC underwent a cine-mode CT perfusion acquisition covering the lesion site. The acquisition started 10s after intravenous injection of iodinated contrast material and lasted 50s. On a dedicated workstation, regions of interest (ROI) were traced within the SCC, on a healthy portion of tissue (H), and on the ipsilateral sternocleidomastoid muscle (M). Blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability– surface product (PS) were calculated. Results In SCC, BF, BV and PS were higher compared with H (p<0.0001, p=0.002 and p=0.004, respectively) and M (p<0.0001). Conversely, MTT was lower in SCC than in H (p=0.0009) and M (p=0.0003). All datasets were free from substantial motion artefacts and ROI misregistration phenomena. No substantial discomfort or adverse events were experienced by any of the patients. Conclusion 64-row CT quantitative perfusion imaging allows head and neck SCC to be distinguished from normal tissues.
Eur Radiol (2011) 21: 113–121 DOI 10.1007/s00330-010-1898-0 Received: 20 February 2010, Revised: 6 June 2010, Accepted: 2 July 2010, Published online: 23, July 2010
