Contrast-enhanced magnetic resonance angiography (MRA): evaluation of three different contrast agents at two different doses (0.05 and 0.1 mmol/kg) in pigs at 1.5 Tesla
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : M. Voth & Henrik J. Michaely & C. Schwenke & B. Vos & H. Pietsch
- چاپ و سال / کشور: 2010
Description
Objective To compare the image quality of contrast-enhanced magnetic resonance angiography (CE-MRA) of the supraaortic vessels at 0.05 mmol/kg bw and 0.1 mmol/kg bw, between gadobutrol, Gd-DTPA and Gd-BOPTA quantitatively and qualitatively a total of eight pigs were evaluated intraindividually at 1.5 T. Methods Each pig was examined using 0.1 mmol/kg gadobutrol, Gd-DTPA and Gd-BOPTA on day one and 0.05 mmol/kg on day two. MRA datasets for the carotid artery and the infraorbital artery were qualitatively assessed regarding overall image quality on an ordinal four-point scale (4-excellent, 1-non-diagnostic). The signal-to noiseratio (SNR) was measured. Results The qualitative assessment of the carotid artery showed a higher median image quality for the 0.1 mmol dose than for the 0.05 mmol dose for all three compounds. No difference was found for the infraorbital artery. Mean SNR of Gd-BOPTA, Gd-DTPA, gadobutrol at 0.05 mmol/kg were 36.0±13.4/37.9±16.3/43.7±0.4 and at 0.1 mmol/kg they were 50.1±12.4/46.6±6.5 / 54.6±10.2. Gd-BOPTA 0.05 revealed a significantly lower SNR than all other agents at normal dose. Conclusions Full-dose gadolinium MRA results in higher image quality and significantly higher SNR compared with the half dose. Gadobutrol and Gd-BOPTA have similar enhancement properties at full dose but at half dose, gadobutrol appears superior.
Eur Radiol (2011) 21:337–344 DOI 10.1007/s00330-010-1940-2 Received: 16 May 2010 / Revised: 10 July 2010 / Accepted: 28 July 2010 / Published online: 1 September 2010
