Changes in AVM angio-architecture and hemodynamics after stereotactic radiosurgery assessed by dynamic MRA and phase contrast flow assessments
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Lydia Schuster & E. Schenk & F. Giesel & T. Hauser & L. Gerigk & A. Zabel-Du-Bois & Marco Essig
- چاپ و سال / کشور: 2010
Description
Objectives Assessment of changes in the hemodynamics of Arteriovenous malformations (AVM) induced by radiosurgery by MR Phase contrast (PC) measurements of the internal carotid arteries (ICA). Methods 65 patients shortly after or before stereotactic radiosurgery underwent MRI including morphological series, MR-Angiography (Time-of-flight, dynamic MRA) and bilateral ECG triggered MR phase contrast (PC) measurements of the ICA. Follow-up was performed in 34 patients. The observation period was up to 4 years. Results Over all subjects, a significant relationship between mean arterial blood flow in the ICA on the side of the lesion and AVM volume was revealed (p=0,0002). In large (>10 ccm) and medium-sized AVMs, (>3, 5 .10 ccm) the blood flow was significantly increased on the side of the AVM (p=0,0004; p=0,047), whereas in lesions <3, 5 ccm, no significant rise of the mean blood flow was detectable. At follow-up, the mean blood flow in the ipsilateral artery was not increased anymore compared to the contralateral ICA (p=0,11). These changes correlated with a significant reduction of the average AVM volume (p=0, 0026). Conclusions The AVM angioarchitecture has significant impact on the blood flow in feeding arteries. A significant reduction of the shunt volume by successful radiotherapy leads to normalization of the hemodynamics.
Eur Radiol (2011) 21:1267–1276 DOI 10.1007/s00330-010-2031-0 Received: 19 July 2010 / Accepted: 25 October 2010 / Published online: 22 December 2010
