64-section multidetector CT of the upper abdomen: optimization of a saline chaser injection protocol for improved vascular and parenchymal contrast enhancement
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Daniele Marin & Rendon C. Nelson & Antonino Guerrisi & Huiman Barnhart & Sebastian T. Schindera & Roberto Passariello & Carlo Catalano
- چاپ و سال / کشور: 2011
Description
Objectives To prospectively investigate the effect of varying the injection flow rates of a saline chaser on vascular and parenchymal contrast enhancement during abdominal MDCT. Methods 100 consecutive patients were randomly assigned to four injection protocols. A fixed dose of contrast medium was administered followed by no saline (Protocol A) or 50 mL of saline at 2, 4, or 8 mL/s (Protocols B, C, and D). Peak, time-to-peak, and duration of 90% peak enhancement were determined for aorta, pancreas, and liver. Results Aortic peak enhancement was significantly higher for Protocol D (369.5 HU) compared with Protocols A and B (332.9 HU and 326.0 HU, respectively; P<0.05). Pancreatic peak enhancement was significantly higher for Protocols C and D (110.6 HU and 110.9 HU, respectively) compared to Protocol A (92.5 HU; P<0.05). Aortic and pancreatic time-to-peak enhancement occurred significantly later for Protocol D compared with Protocol A (42.8 s vs. 36.1 s [P<0.001] and 49.7 s vs. 45.3 s [P=0.003]). Conclusions Injecting a saline chaser at high flow rates yields significantly higher peak aortic and pancreatic enhancement, with a slight longer time-to-peak enhancement.
Eur Radiol (2011) 21:1938–1947 DOI 10.1007/s00330-011-2139-x Received: 21 January 2011 / Revised: 19 March 2011 / Accepted: 4 April 2011 / Published online: 11 May 2011
