Incremental value of diffusion weighted and dynamic contrast enhanced MRI in the detection of locally recurrent prostate cancer after radiation treatment: preliminary result
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Oguz Akin & David H. Gultekin & Hebert Alberto Vargas & Junting Zheng & Chaya Moskowitz & Xin Pei & Dahlia Sperling & Lawrence H. Schwartz & Hedvig
- چاپ و سال / کشور: 2011
Description
Objectives To assess the incremental value of diffusionweighted (DW-MRI) and dynamic contrast-enhanced MRI (DCE-MRI) to T2-weighted MRI (T2WI) in detecting locally recurrent prostate cancer after radiotherapy. Methods Twenty-four patients (median age, 70 years) with a history of radiotherapy-treated prostate cancer underwent multi-parametric MRI (MP-MRI) and transrectal prostate biopsy. Two readers independently scored the likelihood of cancer on a 1–5 scale, using T2WI alone and then adding DW-MRI and DCE-MRI. Areas under receiver operating characteristic curves (AUCs) were estimated at the patient and prostate-side levels. The apparent diffusion coefficient (ADC) from DW-MRI and the Ktrans, kep, ve, AUGC90 and AUGC180 from DCE-MRI were recorded. Results Biopsy was positive in 16/24 (67%) and negative in 8/24 (33%) patients. AUCs for readers 1 and 2 increased from 0.64 and 0.53 to 0.95 and 0.86 with MP-MRI, at the patient level, and from 0.73 and 0.66 to 0.90 and 0.79 with MP-MRI, at the prostate-side level (p values<0.05). Biopsy-positive and biopsy-negative prostate sides differed significantly in median ADC [1.44 vs. 1.68 (×10-3 mm2/s)], median Ktrans [1.07 vs. 0.34 (1/min)], and kep [2.06 vs 1.0 (1/min)] (p values<0.05). Conclusions MP-MRI was significantly more accurate than T2WI alone in detecting locally recurrent prostate cancer after radiotherapy.
Eur Radiol (2011) 21:1970–1978 DOI 10.1007/s00330-011-2130-6 Received: 10 November 2010 / Revised: 13 February 2011 / Accepted: 9 March 2011 / Published online: 1 May 2011
