Dual-energy contrast-enhanced digital mammography: initial clinical results
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Clarisse Dromain & Fabienne Thibault & Serge Muller & Françoise Rimareix & Suzette Delaloge & Anne Tardivon & Corinne Balleyguier
- چاپ و سال / کشور: 2010
Description
Objective To assess the diagnostic accuracy of Dual-Energy Contrast-Enhanced Digital Mammography (CEDM) as an adjunct to mammography (MX) versus MX alone and versus mammography plus ultrasound (US). Materials and methods 120 women with 142 suspect findings on MX and/or US underwent CEDM. A pair of low- and high-energy images was acquired using a modified full-field digital mammography system. Exposures were taken in MLO at 2 min and in CC at 4 min after the injection of 1.5 ml/kg of an iodinated contrast agent. One reader evaluated MX, US and CEDM images during 2 sessions 1 month apart. Sensitivity, specificity, and area under the ROC curve were estimated. Results The results from pathology and follow-up identified 62 benign and 80 malignant lesions. Areas under the ROC curves were significantly superior for MX+CEDMthan it was for MX alone and for MX+US using BI-RADS. Sensitivity was higher forMX+CEDMthan it was forMX(93% vs. 78%; p<0.001) with no loss in specificity. The lesion size was closer to the histological size for CEDM. All 23 multifocal lesions were correctly detected by MX+CEDM vs. 16 and 15 lesions by MX and US respectively. Conclusion Initial clinical results show that CEDM has better diagnostic accuracy than mammography alone and mammography+ultrasound.
Eur Radiol (2011) 21:565–574 DOI 10.1007/s00330-010-1944-y Received: 23 April 2010 / Revised: 30 July 2010 / Accepted: 30 July 2010 / Published online: 14 September 2010
