Ultra-high-b-value diffusion-weighted MR imaging for the detection of prostate cancer: evaluation in 201 cases with histopathological correlation
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Kazuhiro Katahira Taro Takahara Thomas C. Kwee Seitaro Oda Yasuko Suzuki Shoji Morishita Kosuke Kitani Yasuyuki Hamada Mitsuhiko Kitaoka Yasu
- چاپ و سال / کشور: 2010
Description
Purpose To assess the diagnostic performance of diffusionweighted magnetic resonance (MR) imaging (DWI) for prostate cancer detection, using different b-values. Methods A total of 201 patients who underwent MR imaging before total prostatectomy were evaluated. MR images were independently assessed by three radiologists. Three combinations of sequenceswere separately evaluated, as follows: group 1 [T2-weighted images (T2WI) alone], group 2 (T2WI and DWI with a b-value of 1,000s/ mm2), group 3 (T2WI and DWI with a b-value of 2,000s/mm2). Whole-mountsection histopathological examination was the reference standard. Areas under the receiver operating characteristic curve (AUCs) and diagnostic performance parameters were determined. Results The sensitivity, specificity, and AUC for the detection of prostate cancer were as follows: 52.2%, 80.7%, and 0.694 in group 1; 61.2%, 82.6%, and 0.755 in group 2; 73.2%, 89.7%, and 0.842 in group 3. Group 3 achieved the highest diagnostic performance, followed by group 2 (P< 0.05). In the transition zone, the specificity was lower (P<0.001) for group 2 (82.2%) than for group 1 (86.2%). Conclusion The addition of diffusionweighted images with a b-value of 2,000s/mm2 to T2WI can improve the diagnostic performance of MR imaging in prostate cancer detection.
Eur Radiol (2011) 21: 188–196 DOI 10.1007/s00330-010-1883-7 Received: 3 March 2010/ Revised: 3 May 2010/ Accepted: 31 May 2010/ Published online: 18 July 2010
