Cerebral blood volume imaging by flat detector computed tomography in comparison to conventional multislice perfusion CT
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Tobias Struffert & Yu Deuerling-Zheng & Stephan Kloska & Tobias Engelhorn & Jan Boese & Michael Zellerhoff & Stefan Schwab & Arnd Doerfler
- چاپ و سال / کشور: 2010
Description
Objective We tested the hypothesis that Flat Detector computed tomography (FD-CT) with intravenous contrast medium would allow the calculation of whole brain cerebral blood volume (CBV) mapping (FD-CBV) and would correlate with multislice Perfusion CT (PCT). Methods Twenty five patients were investigated with FDCBV and PCT. Correlation of the CBV maps of both techniques was carried out with measurements from six anatomical regions from both sides of the brain. Mean values of each region and the correlation coefficient were calculated. Bland-Altman analysis was performed to compare the two different imaging techniques. Results The image and data quality of both PCT and FDCBV were suitable for evaluation in all patients. The mean CBV values of FD-CBV and PCT showed only minimal differences with overlapping standard deviation. The correlation coefficient was 0.79 (p<0.01). Bland-Altman analysis showed a mean difference of -0.077±0.48 ml/100 g between FD-CBV and PCT CBV measurements, indicating that FD-CBV values were only slightly lower than those of PCT. Conclusion CBVmapping with intravenous contrastmedium using Flat Detector CT compared favourably with multislice PCT. The ability to assess cerebral perfusion within the angiographic suite may improve the management of ischaemic stroke and evaluation of the efficacy of dedicated therapies.
Eur Radiol (2011) 21:882–889 DOI 10.1007/s00330-010-1957-6 Received: 26 March 2010 / Revised: 1 August 2010 / Accepted: 2 August 2010 / Published online: 21 September 2010
