Signal profile on Gd-EOB-DTPA-enhanced MR imaging in non-alcoholic steatohepatitis and liver cirrhosis induced in rats: correlation with transporter expression
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Natsuko Tsuda & Osamu Matsu
- چاپ و سال / کشور: 2011
Description
Objectives To compare the transporter expression and signal profile on Gd-EOB-DTPA-enhanced MRI between non-alcoholic steatohepatitis (NASH) and cirrhotic liver induced in rats, and investigate the correlation of the transporter expression and fibrosis rate in both diseases. Methods Forty-eight rats were divided into four groups of 12: TAA (cirrhosis), NASH 7- and 10-week, and control groups. Each group was divided into two subgroups: Group 1 for MRI and Group 2 for transporter examinations. Results The relative enhancement of the TAA group was significantly lower than those of other groups (p<0.01). The Tmax and T1/2 of the NASH 10-week group was significantly prolonged in comparison with the TAA group (p<0.01). There was no significant difference in the oatp1 expression, whereas the mrp2 expression of the TAA group was significantly higher than those of other groups (p<0.01). There was no significant correlation between the fibrosis rate and oatp1 expression, whereas a paradoxical correlation was found between the fibrosis rate and mrp2 expression (NASH: negative correlation, r=0.91, p<0.01; TAA: positive correlation, r=0.85, p<0.01). Conclusions Our findings showed that the mrp2 expression in cirrhosis increases in comparison with NASH, and there was a paradoxical correlation between the fibrosis rate and mrp2 expression.
Eur Radiol DOI 10.1007/s00330-011-2228-x Received: 30 May 2011 / Revised: 14 July 2011 / Accepted: 21 July 2011
