The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis: correlation with gadoxetic acid enhanced MR imaging
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Azusa Kitao & Osamu Matsui & Norihide Yoneda & Kazuto Kozaka & Rieko Shinmura & Wataru Koda & Satoshi Kobayashi & Toshifumi Gabata & Yoh Zen & Tatsu
- چاپ و سال / کشور: 2011
Description
Objectives To clarify the changes in organic aniontransporting polypeptide 8 (OATP8) expression and enhancement ratio on gadoxetic acid-enhanced MR imaging in hepatocellular nodules during multistep hepatocarcinogenesis. Methods In imaging analysis, we focused on 71 surgically resected hepatocellular carcinomas (well, moderately and poorly differentiated HCCs) and 1 dysplastic nodule (DN). We examined the enhancement ratio in the hepatobiliary phase of gadoxetic acid enhanced MR imaging [(1/ postcontrast T1 value-1/precontrast T1 value)/(1/precontrast T1 value)], then analysed the correlation among the enhancement ratio, tumour differentiation grade and intensity of immunohistochemical OATP8 expression. In pathological analysis, we focused on surgically resected 190 hepatocellular nodules: low-grade DNs, high-grade DNs, early HCCs, well-differentiated, moderately differentiated and poorly differentiated HCCs, including cases without gadoxetic acid-enhanced MR imaging. We evaluated the correlation between the immunohistochemical OATP8 expression and the tumour differentiation grade. Results The enhancement ratio of HCCs decreased in accordance with the decline in tumour differentiation (P<0.0001, R=0.28) and with the decline of OATP8 expression (P<0.0001, R=0.81). The immunohistochemical OATP8 expression decreased from low-grade DNs to poorly differentiated HCCs (P<0.0001, R=0.15). Conclusions The immunohistochemical expression of OATP8 significantly decreases during multistep hepatocarcinogenesis, which may explain the decrease in enhancement ratio on gadoxetic acid-enhanced MR imaging.
Eur Radiol DOI 10.1007/s00330-011-2165-8 Received: 3 March 2011 / Revised: 20 April 2011 / Accepted: 30 April 2011
