Acute exacerbation of idiopathic pulmonary fibrosis: high-resolution CTscores predict mortality
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Kiminori Fujimoto & Hiroyuki Taniguchi & Takeshi Johkoh & Yasuhiro Kondoh & Kazuya Ichikado & Hiromitsu Sumikawa & Takashi Ogura & Kensuke Kataoka &
- چاپ و سال / کشور: 2011
Description
Objectives To determine high-resolution computed tomography (HRCT) findings helpful in predicting mortality in patients with acute exacerbation of idiopathic pulmonary fibrosis (AEx-IPF). Methods Sixty patients with diagnosis of AEx-IPF were reviewed retrospectively. Two groups (two observers each) independently evaluated pattern, distribution, and extent of HRCT findings at presentation and calculated an HRCTscore at AEx based on normal attenuation areas and extent of abnormalities, such as areas of ground-glass attenuation and/ or consolidation with or without traction bronchiectasis or bronchiolectasis and areas of honeycombing. The correlation between the clinical data including the HRCT score and mortality (cause-specific survival) was evaluated using the univariate and multivariate Cox-regression analyses. Results Serum KL-6 level, PaCO2, and the HRCT score were statistically significant predictors on univariate analysis. Multivariate analysis revealed that the HRCT score was an independently significant predictor of outcome (hazard ratio, 1.13; 95% confidence interval, 1.06.1.19, P=0.0002). The area under receiver operating characteristics curve for the HRCT score was statistically significant in the classification of survivors or nonsurvivors (0.944; P<0.0001). Survival in patients with HRCT score .245 was worse than those with lower score (logrank test, P<0.0001). Conclusion The HRCT score at AEx is independently related to prognosis in patients with AEx-IPF
Eur Radiol DOI 10.1007/s00330-011-2211-6 Received: 2 March 2011 / Revised: 24 May 2011 / Accepted: 20 June 2011
