A method of adjusting SUV for injection-acquisition time differences in 18F-FDG PET Imaging
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Eric Laffon & Henri de Clermont & Roger Marthan
- چاپ و سال / کشور: 2011
Description
Objective A time normalisation method of tumour SUVs in 18F-FDG PET imaging is proposed that has been verified in lung cancer patients. Methods A two-compartment model analysis showed that, when SUV is not corrected for 18F physical decay (SUVuncorr), its value is within 5% of its peak value (t= 79 min) between 55 and 110 min after injection, in each individual patient. In 10 patients, each with 1 or more malignant lesions (n=15), two PET acquisitions were performed within this time delay, and the maximal SUVof each lesion, both corrected and uncorrected, was assessed. Results No significant difference was found between the two uncorrected SUVs, whereas there was a significant difference between the two corrected ones: mean differences were 0.04±0.22 and 3.24±0.75 g.ml-1, respectively (95% confidence intervals). Therefore, a simple normalisation of decay-corrected SUV for time differences after injection is proposed: SUVN=1.66*SUVuncorr, where the factor 1.66 arises from decay correction at t=79 min. Conclusions When 18F-FDG PET imaging is performed within the range 55–110 min after injection, a simple SUV normalisation for time differences after injection has been verified in patients with lung cancer, with a ±2.5% relative measurement uncertainty.
Eur Radiol DOI 10.1007/s00330-011-2204-5 Received: 18 March 2011 / Revised: 11 May 2011 / Accepted: 12 June 2011
