‘‘Ecstasy’’ associated deaths: what is a fatal concentration ? Analysis of a case series
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : C. M. Milroy
- چاپ و سال / کشور: 2011
Description
Amphetamine derivative drugs, particularly 3,4- methylenedioxymethamphetamine (MDMA), commonly known as ecstasy, are popular recreational drugs. MDMA is associated with causing death by a number of mechanisms, including hyperpyrexia, cardiac arrhythmia water intoxication and liver failure. Seventy-seven deaths where MDMA was detected in body fluids/organs were reviewed. Of these cases 59 deaths had MDMA present in blood. In 13 cases death was attributable to the toxic effects of MDMA alone with a range of 0.478–53.9 mg/l, mean 8.43 mg/l, median 3.49 mg/l. In 22 cases death was due to polydrug use, with an MDMA range of 0.04–41.5 mg/l, mean 2.90 mg/l, median 0.76 mg/l. In 24 cases death was due to trauma with an MDMA range of 0.035–4.81 mg/l, mean 0.862 mg/l, median 0. 483 mg/l. There is considerable overlap between the concentration of MDMA seen in deaths from direct MDMA toxicity and deaths associated with trauma. These findings show, that like other stimulant drugs, no specific concentration can be used to determine death without consideration of the history and full autopsy findings.
Forensic Sci Med Pathol (2011) 7:248–252 DOI 10.1007/s12024-010-9220-7 Accepted: 27 December 2010 / Published online: 25 January 2011
