Recently abused b-keto derivatives of 3,4-methylenedioxyphenylalkylamines: a review of their metabolisms and toxicological analysis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Kei Zaitsu Munehiro Katagi Michiaki Tatsuno Takako Sato Hitoshi Tsuchihashi Koichi Suzuki
- چاپ و سال / کشور: 2011
Description
b-Keto derivatives of 3,4-methylenedioxyphenylalkylamines (bk-MDPAs), especially 2-methylamino- 1-(3,4-methylenedioxyphenyl)propan-1-one (methylone), 2-methylamino-1-(3,4-methylenedioxyphenyl)butan-1-one (bk-MBDB), and 2-ethylamino-1-(3,4-methylenedioxyphenyl) propan-1-one (bk-MDEA), are abused as substitutes for 3,4-methylenedioxyphenylalkylamines in some countries, causing increased social problems. With the widespread abuse of bk-MDPAs, the analysis of bk-MDPAs and their metabolites in human specimens is quite important in forensic and clinical toxicology. In this review, the metabolisms of bk-MDPAs and simultaneous analytical methods for bk-MDPAs and their metabolites by gas chromatography– mass spectrometry, liquid chromatography–mass spectrometry, and liquid chromatography–tandem mass spectrometry are presented.
Forensic Toxicol (2011) 29:73–84 DOI 10.1007/s11419-011-0111-8 Received: 17 January 2011 / Accepted: 15 March 2011 / Published online: 22 April 2011
