Downregulation effects of beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic CD14 expression in rats with liver fibrosis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Jianguo LIU1, MB, Zhe ZHANG2, MM, Jiechang GAO1, MM, Jiwen XIE 1, MB, Lin YANG1, MD, Shenjun HU1, MM
- چاپ و سال / کشور: 2011
Description
It has been demonstrated that â-elemene could protect against carbon tetrachloride (CCl4)-induced liver fibrosis in our laboratory work, and the aim of this paper is to reveal the protective mechanisms of â-elemene. The hepatic fibrosis experimental model was induced by the hypodermical injection of CCl4 in Wistar male rats. â- elemene was intraperitoneally administered into rats for 8 weeks (0.1 mL/100 g bodyweight per day), and plasma endotoxin content was assayed by biochemistry. The serum TNF-ل level was detected using radioactive immunity. CD14 expression in rat livers was measured by immunohistochemistry and Western blot. The results showed that â-elemene can downregulate the levels of plasma endotoxins, serum TNF-ل, and hepatic CD14 expression in rats with liver fibrosis. â-elemene plays an important role in downregulating the lipopolysaccharide signal transduction pathway, a significant pathway in hepatic fibrosis development
Front. Med. 2011, 5(1): 101–105 DOI 10.1007/s11684-011-0111-4 Higher Education Press and Springer-Verlag Berlin Heidelberg 2011
