Gastric linitis plastica: which role for surgical resection?
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Corrado Pedrazzani Daniele Marrelli Fabio Pacelli Maria Di Cosmo Gianni Mura Francesca Bettarini Fausto Rosa Giovanni de Manzoni Fra
- چاپ و سال / کشور: 2011
Description
Background The role of surgery for gastric linitis plastica (GLP) is questioned. This study aimed to analyze our experience in the surgical treatment of GLP with specific reference to the resectability rate, prognosis, and mode of recurrence. Methods Results of surgery were analyzed in 102 patients with GLP. Results Of the 102 patients, 92 underwent surgical exploration, with resection performed in 60 cases. R2 resection was carried out in 20 patients and R1 in 12 patients, while the resection was considered potentially curative (R0) in 28 (27.5%). Overall, the median (95% confidence interval [CI]) survival time was 5.7 (3.7–7.5) months, with none of the patients alive at the end date of the study. For R0 patients the median (95% CI) survival time was 15.8 (11–20.7) months. The great majority of recurrences were intra-abdominal (peritoneal and/or locoregional), with a systemic component of the relapse that was rarely observed (5 cases). Conclusions After primary surgery, GLP showed a poor prognosis without regard to the extent or type of resection. The failure of surgical treatment related mainly to the peritoneal spread of the disease. Specifically designed multimodality treatment protocols should be tested in this setting.
Gastric Cancer DOI 10.1007/s10120-011-0063-z Received: 29 September 2010 / Accepted: 17 May 2011
