Safety and feasibility of S-1 adjuvant chemotherapy for gastric cancer in elderly patients
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Toru Aoyama Takaki Yoshikawa Takafumi Watanabe Tsutomu Hayashi Takashi Ogata Haruhiko Cho Akira Tsuburaya
- چاپ و سال / کشور: 2011
Description
Background The safety and feasibility of administering S-1 adjuvant chemotherapy for gastric cancer has not been fully evaluated in elderly patients. Methods This retrospective study selected patients who underwent curative D2 surgery for gastric cancer, were diagnosed with stage II or III disease, and received adjuvant S-1 at our institution. Patients were categorized into two groups; non-elderly patients (age\70 years: group A) and elderly patients (age C70 years: group B). The toxicity and S-1 continuation rates in the two groups were compared. Results A total of 75 patients were evaluated in the study. There were no grade 4 toxicities. The incidences of grade 3 hematological and non-hematological toxicities were\5% in both groups, and the differences were not significant. The continuation rate at 6 months was 69% in group A and 70% in group B, and this difference was also not significant. Conclusions These results suggest that S-1 adjuvant chemotherapy for gastric cancer is safe and feasible, regardless of the age of the patient; especially for elderly patients who could be candidates for clinical trials
Gastric Cancer DOI 10.1007/s10120-011-0068-7 Received: 17 January 2011 / Accepted: 29 May 2011
