Atrial fi brillation after esophagectomy: an indicator of postoperative morbidity

Purpose. The relevance of new-onset atrial fi brillation (AF) after esophagectomy remains poorly defi ned. This study’s primary goal is to better defi ne the incidence, clinical patterns, and outcomes associated with the development of AF after esophagectomy. Methods. The study is a retrospective review of patients undergoing esophagectomy at a single academic center between May 1996 and December 2007. Patients with new-onset AF were evaluated by univariate and multivariate analyses for risk factors associated with AF onset and outcomes. Results. New-onset AF was noted in 32 of 156 (20.5%) patients after esophagectomy. Most (16/32, 50%) developed AF within 48 h, and 28 of 32 (87.5%) developed new AF within 72 h of surgery. Pulmonary complications were more frequent in patients with AF than those without AF (59.4% vs. 15.3%, P < 0.01) and usually immediately preceded or occurred concurrently with AF. Anastomotic leaks were signifi cantly more common in patients with AF than those without (28.1% vs. 6.45%, P < 0.01) and were identifi ed, on average, 4.2 days after the onset of AF. Inthe multivariate analysis, anastomotic leaks, pulmonary complications, and number of complications were signifi - cantly associated with AF. Although 60-day survival was worse for patients developing AF (P < 0.01), multivariate analysis suggests that non-AF complications were the independent predictor of mortality. Conclusion. New-onset AF after esophagectomy is associated with anastomotic leaks, pulmonary complications, and decreased 60-day survival. Although pulmonary complications typically occurred coincident with the onset of AF, anastomotic leaks were usually diagnosed 4 days after AF onset. New postesophagectomy AF should prompt vigilance for the presence of other concurrent complications.