Pulmonary epithelioid hemangioendothelioma
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Yoshimasa Mizuno, MD, PhD · Hisashi Iwata, MD, PhD Koyo Shirahashi, MD · Yoshinobu Hirose, MD, PhD Hirofumi Takemura, MD, PhD
- چاپ و سال / کشور: 2010
Description
We report two cases of pulmonary epithelioid hemangioendothelioma (PEH). Both patients presented with multiple bilateral pulmonary nodules, <10 mm diameter, on computed tomography (CT). Multiple pulmonary metastases were considered, but no primary malignant lesion was detected by other imaging modalities including 18F-fl uorodeoxyglucose positron emission tomography (18F-FDG-PET)/CT. Moreover, the nodules did not show increased uptake of 18F-FDG. We performed pulmonary wedge resections by video-assisted thoracoscopic surgery (VATS). Histological and immunohistochemical analysis revealed PEH in both. Positivity for the monoclonal antibody MIB-1 in the tumor cells was 5% in the fi rst case and 5%–10% in the second case. Slow tumor progression was detected with CT in the second case. Although 18F-FDG PET/CT is effective for screening other malignant lesions, it does not appear to be of direct use in the diagnosis and surgical planning of PEH. Pathological diagnosis by VATS is the most effective method. MIB-1 positivity should be analyzed as to whether it is a prognostic factor of PEH.
Gen Thorac Cardiovasc Surg (2011) 59:297–300 DOI 10.1007/s11748-010-0651-6 Received: 22 January 2010 / Accepted: 25 May 2010
