Simultaneous double thymic carcinoids: a rare initial manifestation of multiple endocrine neoplasia type 1
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Ryutaro Kikuchi, MD · Nobuya Mino, MD Taku Okamoto, MD · Tadashi Matsukura, MD Takashi Hirai, MD
- چاپ و سال / کشور: 2011
Description
A 53-year-old man was referred to our hospital for treatment of two anterior mediastinal tumors. The anterior mediastinal tumors were resected by thymectomy under the probable diagnosis of double thymomas. The fi nal pathological diagnosis was multiple thymic carcinoids. Although 20%–25% of patients with thymic carcinoid have a family history of multiple endocrine neoplasia type 1 (MEN-1), radiographic screening just after the operation did not detect any endocrine tumors. However, the patient had a urinary calculus 4 months 7 months after the operation. Endocrinological examination then revealed mild hypercalcemia, hypophosphatemia, hyperinsulinemia, and hyperprolactinemia. Radiologically, a parathyroid tumor and a pancreatic tumor were found. The patient was referred to a university hospital and a mutation of MEN-1 gene was detected. The diagnosis of MEN-1 was confi rmed about 1 year after the operation.
Gen Thorac Cardiovasc Surg (2011) 59:68–72 DOI 10.1007/s11748-010-0606-y Received: 18 November 2009 / Accepted: 22 February 2010
