The rate of myocardial infarction events among patients with age-related macular degeneration: a population-based study
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Shani Golan & Varda Shalev & Michaela Goldstein & Giora Treister & Gabriel Chodick & Anat Loewenstein
- چاپ و سال / کشور: 2010
Description
Purpose To examine the association between age-related macular degeneration (AMD) and the risk of myocardial infarctions (MIs) in a large health maintenance organization. Design A retrospective cohort study carried out at Maccabi Healthcare Services (MHS). Participants A total of 6,546 patients aged .65 years who were diagnosed with AMD between April 18 1996 and June 6 2008, and 61,672 non-AMD patients frequencymatched for age and gender. Methods Participants were retrospectively followed to the day of leaving the MHS, to undergoing an MI, or to closure of the study on July 1 2008, whichever came earlier. The relative risk of MI associated with AMD was estimated using the Cox proportional hazard model. Main Outcome Measures Incident myocardial infarction events. Results During the study period, there were 159 (5.1 per 1,000 person years [PY]) and 2,997 (4.2 per 1,000 PY) MIs respecively in the AMD and non-AMD patient groups. The age- and gender-adjusted hazard ratio (HR) of MI among AMD patients was 1.01 (95%CI: 0.85.1.20). Baseline medical characteristics associated with increased risk of mortality included diabetes mellitus, hypertension, older age, and male gender. The fully adjusted HR associated with AMD was 1.03 (95%CI: 0.87.1.22). Conclusion Despite the shared risk factors associated with AMD and MIs, we found no increased risk of MI in AMD patients.
Graefes Arch Clin Exp Ophthalmol (2011) 249:179–182 DOI 10.1007/s00417-010-1489-4 Received: 5 May 2010 / Revised: 27 July 2010 / Accepted: 3 August 2010 / Published online: 18 August 2010
