Multifocal iris melanoma treated with total anterior segment palladium-103 plaque radiation therapy
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Vasileois Petousis & Paul T. Finger & Tatyana Milman
- چاپ و سال / کشور: 2010
Description
Background A 73-year-old patient presented in our clinic with multiple pigmented iris nodules in the left eye. Though asymptomatic, there was a reported increase in size and number of the nodules during the past year. Methods Interventional case report describing a biopsyproven multifocal iris melanoma treated with a palladium- 103 plaque to include the entire anterior chamber within the targeted zone. Biopsy was performed utilizing a 25-gauge aspiration-cutter under viscoelastic. The cornea was protected during radiation therapy with the amniotic membrane buffer technique. Evaluation parameters included visual acuity and clinical assessments aided by slit-lamp photography as well as high-frequency ultrasound imaging. Results Plaque radiation therapy was well tolerated. Her visual acuity has remained within five letters at 20/25 at 1-year follow-up. Clinical evaluation revealed no evidence of corneal epitheliopathy, iris neovascularization, or visually significant cataract. High-frequency ultrasound imaging revealed a 15% reduction of the tumor’s height. Serial abdominal imaging revealed no metastatic uveal melanoma. Conclusions We present a biopsy-proven iris diffuse melanoma treated with palladium-103 plaque radiation therapy. Though the entire anterior segment was irradiated, there were no significant side-effects. Local tumor control was excellent during the first postoperative year.
Graefes Arch Clin Exp Ophthalmol (2011) 249:937–940 DOI 10.1007/s00417-010-1590-8 Received: 8 October 2010 / Revised: 19 November 2010 / Accepted: 21 November 2010 / Published online: 14 December 2010
