Three-year canaloplasty outcomes for the treatment of open-angle glaucoma: European study results
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Holger Bull & Kurt von Wolff & Norbert Körber & Manfred Tetz
- چاپ و سال / کشور: 2011
Description
Background To report 3-year results investigating the safety and efficacy of canaloplasty, a procedure involving circumferential viscodilation of Schlemm’s canal and tensioning of the inner canal wall to treat open-angle glaucoma. Methods This was a prospective, multi-center, interventional study of 109 eyes of 109 adult, open-angle glaucoma patients undergoing canaloplasty or combined cataractcanaloplasty surgery. Qualifying preoperative intraocular pressures (IOP) were at least 16 mmHg with historical IOPs of at least 21 mmHg with or without medical therapy. A flexible microcatheter was used to viscodilate the full circumference of the canal and to place a trabecular tensioning suture. Primary outcome measures included IOP, glaucoma medication usage, and adverse events. Results Eyes with canaloplasty showed a mean baseline IOP of 23.0±4.3 mmHg and mean glaucoma medication usage of 1.9±0.7 medications, which decreased to a mean IOP of 15.1±3.1 mmHg on 0.9±0.9 medications at 3 years postoperatively. Eyes with combined cataract-canaloplasty surgery showed a mean baseline IOP of 24.3±6.0 mmHg on 1.5±1.2 medications, which decreased to a mean IOP of 13.8±3.2 mmHg on 0.5±0.7 medications at 3 years. Intraocular pressure and medication use results for all study eyes were significantly decreased from baseline (p <0.00001) at all intervals. Late postoperative complications included cataracts (19.1%) and transient IOP elevation (1.8%). Conclusions Canaloplasty demonstrated significant and sustained IOP reductions accompanied by an excellent short- and long-term safety profile in adult patients with open-angle glaucoma.
Graefes Arch Clin Exp Ophthalmol DOI 10.1007/s00417-011-1728-3 Received: 18 January 2011 / Revised: 24 April 2011 / Accepted: 1 May 2011
