Assessment of neovascular permeability in a pancreatic tumor model using dynamic contrast-enhanced (DCE) MRI with contrast agents of different molecular weights
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Louke J. Delrue · Veerle Casneuf · Nancy Van Damme · Peter Blanckaert · Marc Peeters · Wim P. Ceelen · Philippe C. O. Duyck
- چاپ و سال / کشور: 2011
Description
Object We evaluated the relationship of dynamic contrastenhanced magnetic resonance imaging (DCE-MRI)-derived pharmacokinetic parameters and contrast agents with different molecular weights (MW) in a pancreatic tumor mouse model. Materials and methods Panc02 tumors were induced in mice at the hind leg. DCE-MRI was performed using Gadolinium (Gd)-based contrast agents with different MW: Gd-DOTA (0.5 kDa), P846 (3.5 kDa), and P792 (6.47 kDa). Quantitative vascular parameters (AUC, Ktrans, Ve, and Vp) were calculated according to amodified Tofts two-compartment model. Values for all contrast groups were compared for tumor and control (muscle) tissues. Results Values for Ktrans and Ve were significantly higher in tumor tissue than in muscle tissue. When comparing contrast agents, lowest absolute Ktrans values were observed using P792. The relative increase in Ktrans in tumor tissue compared with normal tissue was highest after the use of P792. In both tumor and normal tissues, Ktrans decreased with increasing molecular weight of the contrast agent used. Conclusion It was demonstrated that values for the different DCE-MRI vascular (permeability) parameters are highly dependent on the contrast agent used. Due to their potential to better differentiate tumor from muscle tissue, higher molecular weight contrast agents show promise when evaluating tumors using DCE-MRI.
Magn Reson Mater Phy (2011) 24:225–232 DOI 10.1007/s10334-011-0256-9 Received: 18 November 2010 / Revised: 6 April 2011 / Accepted: 26 April 2011 / Published online: 13 May 2011
