Phase-based arterial input functions in humans applied to dynamic contrast-enhanced MRI: potential usefulness and limitations
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Anders Garpebring · Ronnie Wirestam · Jun Yu · Thomas Asklund · Mikael Karlsson
- چاپ و سال / کشور: 2011
Description
Object Phase-based arterial input functions (AIFs) provide a promising alternative to standard magnitude-based AIFs, for example, because inflow effects are avoided. The usefulness of phase-based AIFs in clinical dynamic contrast-enhanced MRI (DCE-MRI) was investigated, and relevant pitfalls and sources of uncertainty were identified. Materials and methods AIFs were registered from eight human subjects on, in total, 21 occasions. AIF quality was evaluated by comparing AIFs from right and left internal carotid arteries and by assessing the reliability of blood plasma volume estimates. Results Phase-based AIFs yielded an average bolus peak of 3.9mMand a residual concentration of 0.37mMafter 3min, (0.033 mmol/kg contrast agent injection). The average blood plasma volumewas 2.7%when using the AIF peak in the estimation, butwas significantly different (p < 0.0001) and less physiologically reasonable when based on the AIF tail concentration. Motion-induced phase shifts and accumulation of contrast agent in background tissue regions were identified as main sources of uncertainty. Conclusion Phase-based AIFs are a feasible alternative to magnitude AIFs, but sources of errors exist, making quantification difficult, especially of theAIF tail. Improvement of the technique is feasible and also required for the phase-based AIF approach to reach its full potential
Magn Reson Mater Phy (2011) 24:233–245 DOI 10.1007/s10334-011-0257-8 Received: 4 January 2011 / Revised: 8 April 2011 / Accepted: 3 May 2011 / Published online: 29 May 2011
