Motor cortical reorganization is present after a single attack of multiple sclerosis devoid of cortico-spinal dysfunction
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Audrey Rico · Wafaa Zaaraoui · Jerome Franques · Shahram Attarian · Françoise Reuter · Irina Malikova · Sylviane Confort-Gouny · Elisabeth Soulier ·
- چاپ و سال / کشور: 2011
Description
Object While occurrence of motor cortical reorganization has been clearly demonstrated in patients with multiple sclerosis (MS), it is not yet clear whether this cortical reorganization constitutes a response to cortico-spinal lesions or to more diffuse damage affecting the neuronal network involved in motor act preparation, or both. We proposed to investigate the changes in the activation pattern during a simple motor task devoid of cortico-spinal dysfunction occurring in patients with clinically isolated syndrome (CIS) suggestive of MS. Materials and methods Among 15 right-handed CIS patients, we selected eight patients with a preserved central motor pathway established by motor evoked potentials. Ten healthy right-handed gender- and age-matched volunteers were also included. After morphological MRI, subjects performed calibrated conjugated finger flexion and extension movements during fMRI acquision. Results In CIS patients, simple movements of the nondominant hand induced recruitment of the anterior cingulate cortex (BA32) usually involved in complex motor movements. This reorganization was correlated with the diffuse brain tissue damage (brain T2 lesion load). Conclusion These results suggest that at least part of the cortical reorganization observed during very simple tasks in the earliest stage of MS occurs whether or not the efferent pathways are intact.
Magn Reson Mater Phy (2011) 24:77–84 DOI 10.1007/s10334-010-0232-9 Received: 10 June 2010 / Revised: 21 October 2010 / Accepted: 26 October 2010 / Published online: 17 December 2010
