Correlation between arterial blood volume obtained by arterial spin labelling and cerebral blood volume in intracranial tumours
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Danielle van Westen · Esben T. Petersen · Ronnie Wirestam · Roger Siemund · Karin Markenroth Bloch · Freddy Stهhlberg · Isabella M. Bjِrkman-Burtsch
- چاپ و سال / کشور: 2011
Description
Objective To compare measurements of the arterial blood volume (aBV), a perfusion parameter calculated from arterial spin labelling (ASL), and cerebral blood volume (CBV), calculated from dynamic susceptibility contrast (DSC)MRI. In the clinic, CBV is used for grading of intracranial tumours. Materials and methods Estimates of aBV from the modelfree ASL technique quantitative STAR labelling of arterial regions (QUASAR) experiment and of DSC-CBV were obtained at 3T in ten patients with eleven tumours (three grade III gliomas, four glioblastomas and four meningiomas, two in one patient). Parametric values of aBV and CBV were determined in the tumour as well as in normal grey matter (GM), and tumour-to-GM aBV and CBV ratios were calculated. Results In a 4-pixel ROI representing maximal tumour values, the coefficient of determination R2 was 0.61 for the comparison of ASL-based aBV tumour-to-GM ratios and DSC-MRI-based CBV tumour-to-GM ratios and 0.29 for the comparison of parametric values of ASL-aBV and DSC-CBV, under the assumption of proportionality. Both aBV and CBV showed a non-significant tendency to increase when going from grade III gliomas to glioblastomas to meningiomas. Conclusion These results suggest that measurement of aBV is a potential tool for non-invasive assessment of blood volume in intracranial tumours.
Magn Reson Mater Phy (2011) 24:211–223 DOI 10.1007/s10334-011-0255-x Received: 25 January 2010 / Revised: 30 March 2011 / Accepted: 20 April 2011 / Published online: 19 May 2011
