Clinical significance of the ratio between the alpha 2 plasmin inhibitor–plasmin complex and the thrombin–antithrombin complex in advanced non-small cell lung cancer
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Katsuhiro Masago • Shiro Fujita • Tadashi Mio • Yosuke Togashi • Young Hak Kim • Yukimasa Hatachi • Akiko Fukuhara • Kaoru Irisa • Yuichi Sakamori • M
- چاپ و سال / کشور: 2010
Description
The aims of this study are to: (a) confirm the prognostic significance of the procoagulant molecules D dimer, thrombin–antithrombin complex (TAT), and plasmin- a2–plasmin inhibitor complex (PIC); (b) to evaluate hemostatic activation in patients with advanced non-small cell lung cancer (NSCLC); and (c) to delineate the relationships between markers of hemostasis and other clinical characteristics. In this study, a low PIC/TAT ratio and poor PS were significant independent negative prognostic factors for survival in patients with advanced NSCLC. The PIC/TAT ratio may become a surrogate marker for treatment with anticoagulants in the future.
Med Oncol (2011) 28:351–356 DOI 10.1007/s12032-010-9454-y Received: 31 January 2010 / Accepted: 15 February 2010 / Published online: 19 March 2010
