Lack of significant association between TGF-b1 -590C/T polymorphism and breast cancer risk: a meta-analysis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Yongsheng Huang • Youjin Hao • Binghui Li • Jingtian Xie • Ji Qian • Chen Chao • Long Yu
- چاپ و سال / کشور: 2010
Description
Transforming growth factor b1 (TGF-b1) is a cytokine that plays an important role in the control of cell proliferation and differentiation in breast cancer. The -509C/T polymorphism in the TGF-b1 gene has been implicated in breast cancer risk. However, studies on the association between this polymorphism and breast cancer risk have produced conflicting results. To derive a more precise estimation of the relationship, a meta-analysis of the -509C/T polymorphism (5,825 cases and 7,953 controls) from seven published case–control studies was performed. Our analysis suggests that -509C/T has no association with breast cancer risk when using either dominant [odds ratio (OR) = 1.01, 95% confidence intervals (CI): 0.82–1.24], or recessive models (OR = 0.91, 95% CI: 0.66–1.27), or other genetic models to analyze the data. In ethnic subgroups analysis, -509C/T also did not appear to be a risk factor for breast cancer. However, larger scale primary studies are still required to further evaluate the interaction of TGF-b1 -509C/T polymorphism and breast cancer risk in specific populations.
Med Oncol (2011) 28:424–428 DOI 10.1007/s12032-010-9491-6 Received: 22 February 2010 / Accepted: 10 March 2010 / Published online: 27 March 2010
